Prophylactic administration of metformin alleviates withdrawal symptoms associated with heroin
Overall, our data suggests that prophylactic administration of metformin has a therapeutic effect on glial-induced neuroinflammation and neuronal apoptosis in heroin withdrawal mice. Histological experiments suggested that metformin reduced microglia-mediated neuroinflammation and downregulated TLR4 and BAX expressions in the hippocampus.
Authors
- Xinrong Tao (ORCID: https://orcid.org/0000-0002-2106-6039)
- Gongliang Zhang
- Xiaolong Wu (ORCID: https://orcid.org/0000-0001-9059-0005)
- Junyu Jiang (ORCID: https://orcid.org/0000-0003-0207-8832)
- Shanshan Ling (ORCID: https://orcid.org/0000-0003-4801-1027)
- Jiaxin Liu (ORCID: https://orcid.org/0000-0001-6105-8925)
- Minghong Liu (ORCID: https://orcid.org/0000-0002-5102-1915)
- Yuanhai Li
- Yang Liu (ORCID: https://orcid.org/0000-0002-7014-4187)
- Hui‐Chun Chen
- Gang Pang (ORCID: https://orcid.org/0000-0002-8982-9506)
Institutions
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Huainan Mining Industry Group (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1647624
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui University
- Anhui University of Science and Technology