COMPARATIVE STUDY OF SODIUM OXAMATE AND METFORMIN CYTOTOXICITY AGAINST LEWIS LUNG CARCINOMA CELLS UNDER ANCHORAGE-INDEPENDENT GROWTH
Unlike SOX, the cytotoxic effect of MTF on de-adhesive cells was directly related to disrupting energy homeostasis and cell cycle regulation rather than by oxidative stress. Their combined application could potentially reinforce metabolic stress in circulating tumor cells, simultaneously weakening glycolytic and oxidative compensatory pathways, thereby limiting metastatic competence.
Authors
- Denis Kolesnik (ORCID: https://orcid.org/0000-0002-1223-3544)
- G. I. Solyanik (ORCID: https://orcid.org/0000-0002-8657-1263)
- Yu. V. Stepanov
- M Soldatkina (ORCID: https://orcid.org/0009-0007-3069-2254)
- I. Prokhorova
- Yu.R. Yakshibaeva
Institutions
- R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (UA)
Publication Details
- Journal
- Experimental Oncology
- Published
- 2025-10-07
- DOI
- https://doi.org/10.15407/exp-oncology.2025.02.188
- Primary Topic
- Biopolymer Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Ukraine
- National Research Foundation