Sensitivity of familial high-risk approaches for the identification of future bipolar disorder: A longitudinal total birth cohort study
Only a small proportion (7.8 %) of BD cases are identified using the FHR-BD approach. Our findings highlight the importance of prediction research investigating not only absolute or relative risk, but also the sensitivity of different approaches to identifying risk.
Authors
- Marius Lahti‐Pulkkinen (ORCID: https://orcid.org/0000-0002-5244-5525)
- Eero Kajantie (ORCID: https://orcid.org/0000-0001-7081-8391)
- Colm Healy (ORCID: https://orcid.org/0000-0001-7974-1861)
- Jonah F. Byrne (ORCID: https://orcid.org/0000-0002-7046-0630)
- Daniel J. Smıth (ORCID: https://orcid.org/0000-0002-2267-1951)
- Ian Kelleher (ORCID: https://orcid.org/0000-0003-1484-651X)
- Johanna Metsälä (ORCID: https://orcid.org/0000-0003-3806-1020)
- Ulla Lång (ORCID: https://orcid.org/0000-0002-1399-0635)
Institutions
- University College Dublin (IE)
- University of Helsinki (FI)
- Finnish Institute for Health and Welfare (FI)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1016/j.jad.2025.120394
- Citations
- 1
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Department for Business, Energy and Industrial Strategy, UK Government
- Government of the United Kingdom