ALPHA-TOCOPHEROL AND G-CSF CHANGE EXPRESSION OF GENES ASSOCIATED WITH DIFFERENTIATION OF K562 CHRONIC MYELOID LEUKEMIA CELLS DOWNREGULATING EMT-ASSOCIATED STEMNESS BIOMARKERS
The inverse relationship between expression of the genes of leukemic stemness cell markers SNAIL, OCT4, and PLAP and the genes of myeloid differentiation markers C/EBPα, TNAP, and E-cadherin in K562 cells exposed to alpha-tocopherol or G-CSF suggests the activation of the molecular pattern of myeloid differentiation in this setting.
Authors
- Г. Д. Телегеев (ORCID: https://orcid.org/0000-0003-0270-4397)
- М. В. Дыбков (ORCID: https://orcid.org/0000-0002-1512-6250)
- І. Р. Гартовська
- М.П. Завелевич (ORCID: https://orcid.org/0000-0001-6778-7205)
- L. P. Shvachko (ORCID: https://orcid.org/0000-0002-1393-5038)
Institutions
- R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (UA)
- Kyiv City Clinical Oncology Center (UA)
- Institute of Molecular Biology and Genetics (UA)
Publication Details
- Journal
- Experimental Oncology
- Published
- 2025-10-07
- DOI
- https://doi.org/10.15407/exp-oncology.2025.02.181
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science Foundation Ireland