Impact of Concomitant Methotrexate Use and Prior Biologic Disease‐Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized
Tofacitinib was efficacious for patients regardless of baseline concomitant MTX treatment or prior bDMARD exposure; MTX may have a protective effect for flare upon tofacitinib withdrawal. Safety was consistent with the known tofacitinib profile, and no new risks were identified in these subgroups.
Authors
- Lyudmila Grebenkina
- Betül Sözeri (ORCID: https://orcid.org/0000-0002-5079-5644)
- Sampath Prahalad (ORCID: https://orcid.org/0000-0003-3489-1756)
- Carlos Abud‐Mendoza (ORCID: https://orcid.org/0000-0002-3749-5831)
- Hermine I. Brunner (ORCID: https://orcid.org/0000-0001-9478-2987)
- Iris Reyhan (ORCID: https://orcid.org/0000-0002-7917-0402)
- D. Kingsbury
- О.B. Synoverska (ORCID: https://orcid.org/0000-0003-1072-3782)
- Yulia Vyzhga (ORCID: https://orcid.org/0000-0002-3237-9962)
- Елена Жолобова (ORCID: https://orcid.org/0000-0002-2835-2839)
- Irit Tirosh (ORCID: https://orcid.org/0000-0002-0666-5850)
- Abbas Ebrahim (ORCID: https://orcid.org/0000-0002-8100-9677)
- Sheetal S. Vora (ORCID: https://orcid.org/0000-0003-2036-8622)
- Daniel J. Lovell (ORCID: https://orcid.org/0000-0003-1604-0130)
- Klaus Pietzner (ORCID: https://orcid.org/0000-0003-2056-1668)
- Nicolino Ruperto (ORCID: https://orcid.org/0000-0001-8407-7782)
- Gosford Sawyerr
- Peter Chiraseveenuprapund (ORCID: https://orcid.org/0000-0002-6551-1384)
- Alberto Spindler
- Alberto Martini
- Kevin D. Roberts
- Annette Diehl
- Andrea Shapiro (ORCID: https://orcid.org/0009-0001-0458-4096)
- Andreas Blum
- Lisa F. Imundo
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Ivano-Frankivsk National Medical University (UA)
- Children's Hospital of Los Angeles (US)
- Sechenov University (RU)
- Pfizer (United States) (US)
- University of Utah (US)
- Columbia University Irving Medical Center (US)
- Togliatti State University (RU)
- Pfizer (Germany) (DE)
- Randall Children's Hospital at Legacy Emanuel (US)
- Hospital Central Dr. Ignacio Morones Prieto (MX)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Russian Children's Clinical Hospital (RU)
- Levine Children's Hospital (US)
- Centro Científico Tecnológico - Tucumán (AR)
- National Pirogov Memorial Medical University, Vinnytsya (UA)
- Edmond and Lily Safra Children's Hospital (IL)
- Children's Healthcare of Atlanta (US)
- Hospital Privado (AR)
- University of Cincinnati (US)
- University of Milano-Bicocca (IT)
- University of Genoa (IT)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/acr2.70097
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer