Potential Bias in Self‐Controlled Case Series Design: Impact of Incident Versus Prevalent Scenarios of Exposure and Outcome
In prevalent exposure scenarios, IRRs in both studies were attenuated, consistent with prevalent user bias. In prevalent outcome scenarios, where survivor bias was anticipated, no notable shifts in IRRs were observed, possibly due to the high severity and low recurrence of the outcomes associated with the respective exposures. Further consideration of prevalent user and survivor bias is important when interpreting SCCS results. Additional research is needed to quantify the impact of varying exposure and outcome definitions on SCCS estimates.
Authors
- G. C. Lim (ORCID: https://orcid.org/0000-0002-1801-1045)
- Ju Hwan Kim (ORCID: https://orcid.org/0000-0001-7253-6515)
- Hyesung Lee (ORCID: https://orcid.org/0000-0001-6556-9984)
- Ju‐Young Shin (ORCID: https://orcid.org/0000-0003-1010-7525)
- Seong Jun Byun (ORCID: https://orcid.org/0000-0001-6626-8139)
- Jeong‐Eun Lee (ORCID: https://orcid.org/0000-0003-3119-2087)
- Kyungyeon Jung
Institutions
- Kangwon National University (KR)
- Syneos Health (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/pds.70234
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea