Maternal bioactive lipids during pregnancy and early childhood neurodevelopment and behavior
Previous studies suggest potential roles of maternal PUFAs and oxylipins during pregnancy on child NDP and EBP, as these bioactive lipids play crucial roles in immune response, inflammation, and oxidative stress. In this cohort study, we found several associations between maternal bioactive lipid levels during pregnancy and child neurodevelopment and behavior from 1 to 3 years of age. The associations were attenuated after excluding preterm children, suggesting a potential mediating role of preterm birth. Additionally, distinct patterns emerged based on both the inflammatory properties of the bioactive lipids and child sex.
Authors
- Lixia Zeng (ORCID: https://orcid.org/0009-0008-1650-7929)
- Zaira Rosario-Pabón
- Megan Woodbury (ORCID: https://orcid.org/0000-0003-1444-2603)
- Deborah J. Watkins (ORCID: https://orcid.org/0000-0002-6692-2206)
- José F. Cordero (ORCID: https://orcid.org/0000-0002-0564-6391)
- John D. Meeker (ORCID: https://orcid.org/0000-0001-8357-5085)
- Akram N. Alshawabkeh (ORCID: https://orcid.org/0000-0001-5243-4087)
- Seonyoung Park (ORCID: https://orcid.org/0000-0002-1865-1050)
- Sung Kyun Park (ORCID: https://orcid.org/0000-0001-9981-6250)
- Carmen M. Vélez-Vega (ORCID: https://orcid.org/0000-0002-3147-4597)
- Bhramar Mukherjee (ORCID: https://orcid.org/0000-0003-0118-4561)
- Subramaniam Pennathur (ORCID: https://orcid.org/0000-0003-3628-6883)
- Gredia Huerta Montañez
- Wei Hao (ORCID: https://orcid.org/0000-0002-5367-1479)
Institutions
- Northeastern University (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- University of Georgia (US)
- University of Michigan (US)
- Yale University (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1038/s41390-025-04465-4
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences