Impact of IS26 mobilization on genetic manipulation of multidrug-resistant Acinetobacter baumannii
IS26 is prevalent in <i>A. baumannii</i> genomes (78.1%, 698/931), particularly among strains belonging to IC2 (99.8%, 509/510), implying its significant role in the evolution and success of IC2. The potential implications of active IS26 transposition for gene editing and screening warrant careful consideration beyond just <i>A. baumannii</i>.
Authors
- Junjie Zheng (ORCID: https://orcid.org/0000-0002-3031-3556)
- Yanan Gong (ORCID: https://orcid.org/0000-0002-6700-2399)
- Jianzhong Zhang (ORCID: https://orcid.org/0000-0001-7056-8206)
- Lihua He (ORCID: https://orcid.org/0000-0002-8391-6035)
- Yuan Hu (ORCID: https://orcid.org/0000-0002-3031-9341)
- Fanliang Meng (ORCID: https://orcid.org/0000-0003-0518-8893)
Institutions
- Chinese PLA General Hospital (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fmicb.2025.1689239
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00