High mesothelin expression is associated with low cytotoxic T cell infiltration in pancreatic cancer
This study revealed an inverse relationship between MSLN expression and cytotoxic T cell infiltration in PDAC, despite a trend toward improved relapse-free survival in MSLN-high tumors. These findings have important implications for MSLN-targeted immunotherapies and suggest that addressing the immunosuppressive microenvironment may be necessary to optimize their current responses in PDAC.
Authors
- Joo‐Shik Shin (ORCID: https://orcid.org/0000-0001-7840-3625)
- Sharon M. Sagnella
- Timothy Fielder (ORCID: https://orcid.org/0000-0002-8014-6143)
- Dannel Yeo (ORCID: https://orcid.org/0000-0002-6546-1209)
- O Liang (ORCID: https://orcid.org/0000-0002-2481-7264)
- Amy White (ORCID: https://orcid.org/0000-0001-8226-615X)
- Ulf Schmitz (ORCID: https://orcid.org/0000-0001-5806-4662)
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
- James Cook University (AU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1651687
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- NSW Health Pathology
- Cancer Institute NSW
- Townsville Hospital and Health Service
- PanKind, The Australian Pancreatic Cancer Foundation
- Tour de Cure
- Medical Research Council