Production of functional CD19 CAR T cells under hypoxic manufacturing conditions
We demonstrated that production in 2% O<sub>2</sub> is not detrimental, confers subtle but lasting functional and phenotypic changes in CAR T cells warranting further research on the impact of hypoxic production on CAR T cell functionality in hypoxic tumor microenvironments.
Authors
- Mahdi Mohammadpour (ORCID: https://orcid.org/0000-0002-5312-3229)
- Jinhye Ryu
- Isabella Micallef Nilsson
- Anna Schurich (ORCID: https://orcid.org/0000-0002-2525-3114)
- Anders Österborg (ORCID: https://orcid.org/0000-0001-6489-4865)
- Isabelle Magalhaes (ORCID: https://orcid.org/0000-0003-0440-6924)
- Thomas Poiret (ORCID: https://orcid.org/0000-0003-1965-3522)
- Jonas Mattsson (ORCID: https://orcid.org/0000-0002-2163-6644)
- Johan Henriksson (ORCID: https://orcid.org/0000-0002-7745-2844)
Institutions
- Karolinska University Hospital (SE)
- King's College London (GB)
- Princess Margaret Cancer Centre (CA)
- Karolinska Institutet (SE)
- King's College School (GB)
- Umeå University (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1675786
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Cancerfonden
- Karolinska Institutet
- Vetenskapsrådet
- Center for Innovative Medicine
- National Cancer Institute