DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk
This study provides supportive evidence for a regulatory pathway in which DNA methylation at cg18095732 up-regulates ZDHHC20 and is associated with lower acne susceptibility. Our findings highlight epigenetic regulation as a potential biomarker or intervention point for inflammatory skin disorders.
Authors
- Shuhui Wu (ORCID: https://orcid.org/0000-0002-2167-1837)
- Xiaoyue Ji (ORCID: https://orcid.org/0009-0002-0432-278X)
- Mingfang Zhu (ORCID: https://orcid.org/0000-0001-8379-2178)
- Dan Zhao (ORCID: https://orcid.org/0009-0007-7491-5026)
- Ke Gong (ORCID: https://orcid.org/0000-0002-3858-828X)
Institutions
- Cangzhou Central Hospital (CN)
- People's Hospital of Cangzhou (CN)
- Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical Cosmetic and Investigational Dermatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ccid.s552840
- Citations
- 1
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China