Proof of concept for high-dose Cannabidiol pretreatment to antagonize opioid induced persistent apnea in mice
CBD may be an effective preventative therapy for OIPA by increasing the time before apnea onset and potentially enhancing the efficacy of naloxone as an additional strategy to save lives.
Authors
- Evgeny Bondarenko (ORCID: https://orcid.org/0000-0003-0631-8936)
- Beth M. Wiese (ORCID: https://orcid.org/0000-0003-4111-295X)
- Jack L. Feldman (ORCID: https://orcid.org/0000-0003-3692-9412)
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fnins.2025.1654787
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute