Multi-omics analysis reveals Angelica dahurica radix extract alleviates migraine in rats via gut microbiota-metabolome-gut-brain axis regulation
Baizhi alleviates migraine through multi-target coordination: reinforcing gut barrier function, enriching anti-inflammatory <i>Lactobacillus</i>, and restoring neurotransmitter/neurovascular homeostasis through 2-AG-mediated CGRP1 inhibition. These findings bridge traditional herbology with modern neuromicrobiology, positioning BZ as a promising gut microbiota-modulating therapy for migraine.
Authors
- Xun Shen (ORCID: https://orcid.org/0000-0002-8827-5791)
- Junke Li
- Jun Luo (ORCID: https://orcid.org/0000-0002-7351-8180)
- Wuwen Feng (ORCID: https://orcid.org/0000-0001-7850-5357)
- Qing X. Li (ORCID: https://orcid.org/0000-0003-4589-2869)
- Jieyu Sun
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-0564-7167)
- Guihua Jiang (ORCID: https://orcid.org/0000-0002-8957-0477)
- Mei Xue (ORCID: https://orcid.org/0000-0002-2901-2801)
- Jiawen Zhao (ORCID: https://orcid.org/0009-0002-4129-8571)
- Yunlan Lian
- Zhengkun Gan
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1650296
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province