Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice
Our findings suggest that TX significantly attenuated Mn-induced TH reduction and behavioral deficits in REST cKO, not to the levels of its protection in WT, since several genes involved in TX-induced protective pathways required dopaminergic REST. Taken together, while TX has some REST-independent protective effects, dopaminergic REST is critical for full neuroprotection.
Authors
- Edward Pajarillo (ORCID: https://orcid.org/0000-0002-5044-7607)
- Michael Aschner (ORCID: https://orcid.org/0000-0002-2619-1656)
- Alexis Digman (ORCID: https://orcid.org/0000-0002-9308-464X)
- Sanghoon Kim (ORCID: https://orcid.org/0000-0001-9811-2972)
- Eun-Sook Lee (ORCID: https://orcid.org/0000-0001-7047-5288)
- Deok-Soo Son
- Itunu Ajayi
Institutions
- Meharry Medical College (US)
- Albert Einstein College of Medicine (US)
- Florida Agricultural and Mechanical University (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1627400
- Citations
- 1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91