circWWC3 enhances the progression of triple-negative breast cancer by interacting with vimentin to regulate the secretion of CSF2
Overall, our findings reveal that elevated expression of circWWC3 serves a role in the malignant progression of TNBC by directly interacting with the S56 phosphorylation site of vimentin, an interaction that is associated with increased secretion of CSF2. Furthermore, circWWC3 emerges as a potential biomarker for breast cancer diagnosis and presents an attractive therapeutic target for the treatment of TNBC.
Authors
- Yifan Du
- Xiaojun Tang (ORCID: https://orcid.org/0000-0001-8757-0927)
- Ming Wu (ORCID: https://orcid.org/0000-0001-8326-4076)
- Yan Li (ORCID: https://orcid.org/0000-0002-8856-4083)
- Fei Liu (ORCID: https://orcid.org/0000-0002-7013-0981)
- Yuyang Dong (ORCID: https://orcid.org/0000-0001-7112-5212)
- Yang Sang
- Lina Gu (ORCID: https://orcid.org/0000-0001-7787-0678)
- Yang Zheng (ORCID: https://orcid.org/0000-0002-0254-1965)
- Hong Ji (ORCID: https://orcid.org/0000-0002-9382-1988)
Institutions
- Hebei Medical University (CN)
- Shanghai University (CN)
- Shanghai University of Engineering Science (CN)
- Second Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1665608
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00