EXIT-Strategien intrazellulärer Parasiten im Visier hochauflösender Bildgebung

Abstract Living inside host cells provides significant advantages for human parasites like Plasmodium and Leishmania . Nevertheless, to complete their life cycle, they must eventually exit the host cell – a critical step that represents an attractive target for drug development. However, achieving the necessary combination of high spatial and temporal resolution imaging to capture egress dynamics remains a challenge and software pipelines for data analysis need to be advanced. Addressing these challenges will be key to unlocking the exit strategies of parasites.