Comparison of 1064 and 532 nm Picosecond Fractional Lasers for Treating Enlarged Pores and Melanin Spots in Asians: A Randomized Split‐Section Comparison Study

Objective This split‐face randomized study compared the efficacy and safety of 532 and 1064 nm picosecond (ps) fractional lasers for treating enlarged pores and melanin spots. Methods Participants with enlarged facial pores and melanin spots were enrolled and underwent five consecutive sessions of either the 1064 or 532 nm ps fractional laser, with 1‐month intervals between treatments. Images were taken at each visit. Treatment efficacy was assessed by objective (number of pores and melanin spots) and subjective evaluations (patient self‐assessment and a quartile improvement scale). Pain levels, sensation of irritation, and side effects were recorded at subsequent follow‐ups. Results Three Asian males and 22 Asian females were enrolled in this study. At the 2‐month follow‐up after the final treatment, both wavelengths showed a significant reduction in pore numbers on both sides. The respective quartile improvement scale scores showed no significant difference between the two groups. For melanin spot improvement, the mean improvement scale scores were 1.72 ± 0.46 for the 532 nm wavelength and 1.49 ± 0.22 for the 1064 nm wavelength, with the 532 nm wavelength demonstrating a statistically significant and moderately clinically meaningful improvement. Patient assessments showed in pore improvement between the two wavelengths; however, significant improvement in melanin spots was observed for the 532 nm wavelength. The 532 nm wavelength was significantly less painful and irritating. Conclusion The 532 and 1064 nm ps fractional lasers are effective at treating enlarged pores, and although they each demonstrate comparable efficacy, the 532 nm laser also provides simultaneous improvement in melanin spots and is better tolerated.