Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn reduce NPY levels via muscarinic receptor activation
Vagal activation reduces interstitial NPY levels via a pre-synaptic sympathetic M2R mechanism. Y2R inhibition reduces effects of sympathoexcitation and enhances the effects of VNS in vivo. These findings highlight the role of NPY in sympathovagal crosstalk and suggest Y2R as a potential target to modulate autonomic balance.
Authors
- Sartaj Bal
- Valerie Y. H. van Weperen (ORCID: https://orcid.org/0000-0002-0672-9463)
- Jonathan D. Hoang (ORCID: https://orcid.org/0000-0002-3762-9596)
- Maryam Emamimeybodi (ORCID: https://orcid.org/0000-0002-6858-3885)
- Marmar Vaseghi (ORCID: https://orcid.org/0000-0002-9701-9706)
- Benjamin Mothibe Bussmann (ORCID: https://orcid.org/0000-0003-3343-2590)
- Neil R Jani
- Neil Herring (ORCID: https://orcid.org/0000-0001-8453-6133)
- Artin Khaky
- Ashna Kumar (ORCID: https://orcid.org/0000-0001-7086-526X)
- Corey Smith (ORCID: https://orcid.org/0000-0002-4920-4413)
- Thamali Ayagama
- David Hamon
Institutions
- University of Iowa (US)
- University of Oxford (GB)
- Los Angeles Medical Center (US)
- Texas Cardiac Arrhythmia (US)
- Science Oxford (GB)
- Case Western Reserve University (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/cvr/cvaf180
- Citations
- 2
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 2.78