Efficacy and adverse effect profile of vortioxetine in major depressive disorder: A meta-analysis

Vortioxetine is an effective and well-tolerated antidepressant for the management of MDD. Though the tolerability was comparable to other antidepressants, there was a potentially lower incidence of sexual side effects. A further elaborate exploration in terms of dose-specific efficacy and cognitive improvement will be promising for optimizing individualized treatment strategies.

Authors

Arun Selvaraj (ORCID: https://orcid.org/0000-0002-4847-2520)
Velprashanth Venkatesan (ORCID: https://orcid.org/0000-0003-3017-7803)
Reenaa Mohan (ORCID: https://orcid.org/0000-0002-8405-1897)
Barath Ramanathan
Souganya Vijayan (ORCID: https://orcid.org/0009-0006-7859-6037)
Meinaakshi Coumaravelou

Institutions

Sri Manakula Vinayagar Medical College and Hospital (IN)

Publication Details

Journal: Journal of Psychopharmacology
Published: 2025-10-07
DOI: https://doi.org/10.1177/02698811251375106
Primary Topic: Treatment of Major Depression
Type: article
Field-Weighted Citation Impact: 0.00

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article

Efficacy and adverse effect profile of vortioxetine in major depressive disorder: A meta-analysis

Arun Selvaraj, Velprashanth Venkatesan, Reenaa Mohan, Barath Ramanathan et al.

Oct 7, 2025

Journal of Psychopharmacology

Treatment of Major Depression

article

Efficacy and adverse effect profile of vortioxetine in major depressive disorder: A meta-analysis

Arun Selvaraj, Velprashanth Venkatesan, Reenaa Mohan, Barath Ramanathan, Souganya Vijayan, Meinaakshi Coumaravelou

October 7, 2025article en

Abstract

Vortioxetine is an effective and well-tolerated antidepressant for the management of MDD. Though the tolerability was comparable to other antidepressants, there was a potentially lower incidence of sexual side effects. A further elaborate exploration in terms of dose-specific efficacy and cognitive improvement will be promising for optimizing individualized treatment strategies.

Journal of PsychopharmacologyVol. 39(12)

Sri Manakula Vinayagar Medical College and Hospital (IN)

Openalex Percentile: Top 69%

Treatment of Major Depression

DOI Source OpenAlex

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