GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner
GDF15 is implicated in the progression of thyroid cancer and potentially modulates cellular senescence through a p53-dependent mechanism, underscoring its dual functionality as both a pro-tumorigenic driver and a senescence regulator. These findings establish the potential of GDF15 as a therapeutic target and prognostic biomarker in thyroid cancer, providing novel insights developing senescence-centered therapeutic strategies.
Authors
- Changyuan Ding (ORCID: https://orcid.org/0009-0004-9113-4836)
- Zhenpeng Yang (ORCID: https://orcid.org/0000-0002-6814-046X)
- Weili Liang
- Zishuo Liu
- Bin Lv (ORCID: https://orcid.org/0000-0001-9854-0256)
- Xinhua Ma (ORCID: https://orcid.org/0000-0002-6277-0292)
- Rui Hua (ORCID: https://orcid.org/0000-0003-0994-0982)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fendo.2025.1675245
- Citations
- 1
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.67