Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants
Our results reveal a distinct mutational profile in Saudi CRC patients, characterized by novel and enriched somatic variants affecting key oncogenic pathways. These findings underscore the necessity of including underrepresented populations in cancer genomics to support globally equitable precision oncology.
Authors
- Hanan E. Alatwi (ORCID: https://orcid.org/0009-0001-7245-2802)
- Abdulrahman H. Alessa (ORCID: https://orcid.org/0000-0002-8077-4254)
- Othman R. Alzahrani (ORCID: https://orcid.org/0000-0002-2726-0473)
- Amnah A. Alharbi (ORCID: https://orcid.org/0000-0001-9879-9508)
- Yousef M. Hawsawi (ORCID: https://orcid.org/0000-0003-1901-697X)
- Rashid Mir (ORCID: https://orcid.org/0000-0003-2068-3075)
- Mohammed Arishi
- Alanoud Mansour Ayed Albalawi
Institutions
- Alfaisal University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
- Fahd bin Sultan University (SA)
- King Khaled Hospital (SA)
- University of Tabuk (SA)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fonc.2025.1679528
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tabuk