Lactobacillus plantarum-derived cytoplasmic membrane vesicles as novel anti-inflammatory nanotherapeutics for psoriasis management
This study demonstrates that <i>L. plantarum</i>-derived CMVs, enriched with AEA, ameliorate psoriasis through multi-faceted mechanisms including anti-inflammation, antioxidative stress reduction, and reprogramming of macrophage polarization. These findings not only position bacterial nanovesicles as a novel cell-free therapeutic strategy for inflammatory skin diseases but also establish a functional screening platform for precision microbiome-based interventions.
Authors
- Fang Cheng (ORCID: https://orcid.org/0000-0002-8260-9244)
- Yuedong Xie (ORCID: https://orcid.org/0000-0002-9500-7314)
- Quanle Xu (ORCID: https://orcid.org/0000-0002-6303-7500)
- Guochao Lv
- Manchun Li (ORCID: https://orcid.org/0000-0003-4417-3897)
- Hongbo Chen (ORCID: https://orcid.org/0000-0002-0954-5600)
- Dandan Su (ORCID: https://orcid.org/0000-0003-4549-2339)
- Dongling Dai (ORCID: https://orcid.org/0000-0003-4808-3418)
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- North West Agriculture and Forestry University (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1647466
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81