Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome
OAA supplementation was associated with improved cognitive performance and small improvement in UP Time in ME/CFS participants receiving OAA. Fatigue-cognition coupling was particularly strong in OAA-treated participants, suggesting a potentially targetable phenotype. These findings underscore the importance of multidimensional outcome measures in ME/CFS clinical trials and support the need for more research and trials of metabolic interventions in ME/CFS.
Authors
- Brayden Yellman
- David L. Kaufman (ORCID: https://orcid.org/0000-0002-0239-2920)
- Suzanne D. Vernon (ORCID: https://orcid.org/0000-0002-5241-8914)
- Jennifer Bell (ORCID: https://orcid.org/0000-0003-3617-6852)
- Yifei Sun (ORCID: https://orcid.org/0000-0002-5391-9331)
- Alan Cash (ORCID: https://orcid.org/0000-0003-1916-960X)
- Shad Roundy (ORCID: https://orcid.org/0000-0002-5256-628X)
- Lucinda Bateman (ORCID: https://orcid.org/0000-0002-9546-9922)
- Candace Rond
- Bella Rond
Institutions
- University of Utah (US)
- Bateman Horne Center (US)
- US Biologic (United States) (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fneur.2025.1691147
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00