Proton pump inhibitor use and pancreatic risk: evidence from the UK biobank participants and animal experiments
Integrating large-scale cohort data with experimental evidence, our findings suggest that regular PPI use does not meaningfully influence the risk of acute pancreatitis, chronic pancreatitis, or pancreatic cancer.
Authors
- Guotao Lu (ORCID: https://orcid.org/0000-0002-8325-0405)
- Zouhua Xu
- Xiaowu Dong (ORCID: https://orcid.org/0000-0002-2178-4372)
- Keyan Wu (ORCID: https://orcid.org/0000-0003-1635-9862)
- Weiming Xiao (ORCID: https://orcid.org/0000-0002-8893-9076)
- Chenchen Yuan (ORCID: https://orcid.org/0000-0002-0551-0718)
- Qingtian Zhu (ORCID: https://orcid.org/0000-0002-1302-8489)
- Shengfeng Wang (ORCID: https://orcid.org/0000-0001-9397-0409)
- Qingxie Liu (ORCID: https://orcid.org/0009-0006-7968-5103)
- Hongwei Xu (ORCID: https://orcid.org/0000-0002-0470-705X)
- Yaodong Wang (ORCID: https://orcid.org/0000-0001-9671-6035)
- Xiaolei Shi (ORCID: https://orcid.org/0000-0003-3707-6618)
- Xin Gao (ORCID: https://orcid.org/0009-0007-8265-898X)
- Jiajia Pan (ORCID: https://orcid.org/0000-0003-3829-6671)
Institutions
- Peking University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fphar.2025.1673200
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China