Transcriptomic elucidation of Dahuang-Huanglian in promoting white adipose browning in high-fat diet-induced obese rats
DHHL effectively ameliorates HFD-induced obesity in rats, and its therapeutic mechanism is closely associated with the activation of the AMPK/SIRT1/PGC-1α signaling pathway, which promotes the browning of WAT.
Authors
- Min Bai (ORCID: https://orcid.org/0000-0002-6208-0902)
- Bing Song (ORCID: https://orcid.org/0000-0003-4791-083X)
- Zhitao Ni
- Ruiyao Zhang (ORCID: https://orcid.org/0000-0002-5557-5210)
- Chunguang Guo (ORCID: https://orcid.org/0000-0002-3361-9411)
- Xi Xi (ORCID: https://orcid.org/0000-0002-1034-0231)
- Pengcheng Du (ORCID: https://orcid.org/0000-0002-2930-9920)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-5600-003X)
- Yongfeng Wang (ORCID: https://orcid.org/0000-0003-2618-9430)
- Xiaoyan Xu (ORCID: https://orcid.org/0009-0000-6483-7553)
- Yanying Zhang (ORCID: https://orcid.org/0000-0003-1648-4911)
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Ningxia Medical University (CN)
- Pingliang People's Hospital (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fendo.2025.1652703
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00