Predicting severity of cerebral amyloid angiopathy neuropathology: A modeling approach using NACC and ROSMAP data
Cerebral amyloid angiopathy (CAA) severity can only be confirmed postmortem. CAA is associated with an elevated risk of amyloid-related imaging abnormalities (ARIA). The CAA risk score (CAARS) can stratify CAA risks in living patients. Hypertension and apolipoprotein E (APOE) ε4 are risk factors for CAA. The CAARS has the potential to predict risk of ARIA.
Authors
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Liang Jin (ORCID: https://orcid.org/0000-0003-1695-3300)
- Yijun Pan (ORCID: https://orcid.org/0000-0002-1442-3333)
- Benjamin Goudey (ORCID: https://orcid.org/0000-0002-2318-985X)
- Yihan Wang (ORCID: https://orcid.org/0000-0002-5353-6250)
- Liwei Ma (ORCID: https://orcid.org/0000-0002-7867-8060)
- Andrew Huynh (ORCID: https://orcid.org/0000-0002-5848-8040)
- Xinran Cui
- Chenyin Chu
- Megan K. Dunstan
Institutions
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70057
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute on Aging