Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant <i>Enterococcus</i> UTIs?

Urinary tract infections caused by <i>Enterococcus</i> species are a frequent clinical challenge. The rising prevalence of ampicillin resistance often seemingly precludes the use of aminopenicillins. However, evidence suggests that aminopenicillins may retain clinical efficacy, even when susceptibility testing indicates resistance. Integrating available pharmacokinetics/pharmacodynamics and clinical data and risk-benefit considerations, we seek to address the question: Can aminopenicillins still be a viable treatment option in the management of ampicillin-resistant <i>Enterococcus</i> infections?