Association of dietary sodium intake with late‐life cognitive decline and postmortem neuropathology in community‐dwelling older adults
The relation of dietary sodium to brain health is not well understood. In this community-based study, FFQs were used to estimate dietary sodium intake. Longitudinal neurocognitive and postmortem neuropathology evaluations were conducted. Among 1520 older adults without known dementia followed annually for 7.6 years, low sodium intake was associated with faster decline in global cognition. Among a subset who died and came to autopsy, low sodium intake was associated with higher tangle density, but not with amyloid burden or infarcts.
Authors
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Puja Agarwal
- Rupal I. Mehta (ORCID: https://orcid.org/0000-0003-4917-6907)
- A. K. Sood
- Han Tong (ORCID: https://orcid.org/0000-0002-9821-5928)
Institutions
- Rush University Medical Center (US)
- University of Chicago (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70706
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00