White matter hyperintensities precede other biomarkers in <i>GRN</i> frontotemporal dementia
Elevated WMH volumes are found predominantly in symptomatic GRN. WMH accumulation is mostly observed in the frontal lobe. WMH abnormalities appear early in GRN-associated FTD, before NfL, atrophy, and ventriculomegaly. Longitudinally, WMH volumes can predict subcortical changes, but not vice versa. WMHs are key early markers in GRN-associated FTD and should be included in progression models.
Authors
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Reza Rajabli (ORCID: https://orcid.org/0000-0003-1463-0639)
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Robert Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Mahsa Dadar (ORCID: https://orcid.org/0000-0003-4008-2672)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Lize Corrine Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- D. Louis Collins (ORCID: https://orcid.org/0000-0002-8432-7021)
- Vikram Venkatraghavan (ORCID: https://orcid.org/0000-0001-9759-0462)
- Lucy Louise Russell (ORCID: https://orcid.org/0000-0001-5023-5893)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Maxime Bertoux (ORCID: https://orcid.org/0000-0002-5283-503X)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Thibaud Lebouvier (ORCID: https://orcid.org/0000-0002-4386-6045)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Eve Ferry‐Bolder
- Mahdie Soltaninejad
- Isabelle Le Ber
- John C. van Swieten
- Rik Vandenberghe
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Daniela Galimberti
- Yasser Iturria‐Medina
- Robert Laforce
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Jonathan D. Rohrer
- Isabel Santana
- Benedetta Nacmias
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Lisbon (PT)
- University of Toronto (CA)
- University of Milan (IT)
- MRC Cognition and Brain Sciences Unit (GB)
- Universität Ulm (DE)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- London Health Sciences Centre (CA)
- German Center for Neurodegenerative Diseases (DE)
- Health Sciences Centre (CA)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- Centre Hospitalier Universitaire de Lille (FR)
- LMU Klinikum (DE)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Biogipuzkoa Health Research Institute (ES)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Don Carlo Gnocchi Foundation (IT)
- Essen University Hospital (DE)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- Donostiako Unibertsitate Ospitalea (ES)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- University of Florence (IT)
- University College London (GB)
- Amsterdam University of Applied Sciences (NL)
- University of Coimbra (PT)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70695
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Wellcome Trust
- Weston Brain Institute
- National Institute for Health and Care Research
- Department of Health and Social Care
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre