Mitochondrial blood‐based biomarker is related to cardiorespiratory fitness and aging in a sex‐dependent manner
Mitochondrial blood-biomarker shows sex-dependent relationships in aging.Mitochondrial function index is higher in older adult males.Mitochondrial function index declines with age in males.Mitochondrial reactive oxygen species (ROS) are negatively associated with fitness in females.Mitochondrial ROS are negatively associated with lean mass in females.
Authors
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Paul J. Kueck (ORCID: https://orcid.org/0000-0002-9102-2058)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Julie L. Pennington (ORCID: https://orcid.org/0000-0002-2110-3207)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Amanda N. Szabo‐Reed (ORCID: https://orcid.org/0000-0002-4927-1501)
- Riley E. Kemna
- Brittany M Hauger
- Casey S. John
- Hana D. Mayfield
Institutions
- University of Kansas (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70163
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Cancer Institute
- National Institute of General Medical Sciences