Neurovascular de‐coupling underlies dual‐task cost across cognitive abilities
Mobile devices simultaneously assessed neurovascular coupling and dual-task cost.Middle cerebral artery velocity (MCA velocity) is negatively associated with dual-task cost.MCA velocity is associated with gait speed, working memory, and Montreal Cognitive Assessment scores.MCA velocity decreased from controls to mild cognitive impairment to dementia.Novel methodological approach to utilize MCA velocity during overground walking, single-tasks, and dual-tasks.
Authors
- Sarah Best
- Claire Guest (ORCID: https://orcid.org/0000-0002-1169-9246)
- Mamiko Noguchi (ORCID: https://orcid.org/0000-0002-2404-5073)
- Laura K. Fitzgibbon‐Collins (ORCID: https://orcid.org/0009-0002-8268-9843)
- Michael Borrie
- Jaspreet Bhangu (ORCID: https://orcid.org/0000-0003-3934-2967)
- J. Kevin Shoemaker (ORCID: https://orcid.org/0000-0002-6794-5979)
Institutions
- Western University (CA)
- University of Waterloo (CA)
- Parkwood Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70156
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academic Medical Organization of Southwestern Ontario
- University of Waterloo
- Canadian Institutes of Health Research
- Research Institute for Aging, University of Waterloo