IL-1β contributes to neurological disability in NMOSD AQP4 + Patients
Expression of proinflammatory cytokines may differ between NMOSD and RRMS. Elevated IL-1β levels in NMOSD AQP4 + patients are associated with neurological disability, suggesting a potential role as a biomarker of disease severity. Further studies are needed to confirm these findings and evaluate the therapeutic potential of targeting IL-1β in NMOSD.
Authors
- Diego Centonze (ORCID: https://orcid.org/0000-0002-8390-8545)
- Roberta Fantozzi (ORCID: https://orcid.org/0000-0002-7527-575X)
- Georgia Mandolesi (ORCID: https://orcid.org/0000-0003-3612-6820)
- Alessandra Musella (ORCID: https://orcid.org/0000-0001-7889-9253)
- Gianluca Lauritano
- Roberto Furlan (ORCID: https://orcid.org/0000-0001-7376-9425)
- Antonio Bruno (ORCID: https://orcid.org/0000-0003-0976-3410)
- Ettore Dolcetti (ORCID: https://orcid.org/0000-0002-4594-4895)
- Mario Stampanoni Bassi (ORCID: https://orcid.org/0000-0003-4664-850X)
- Veronica Di Caprio (ORCID: https://orcid.org/0000-0002-6026-7298)
- Annamaria Finardi (ORCID: https://orcid.org/0000-0002-7909-2600)
- Francesca De Vito (ORCID: https://orcid.org/0000-0002-6543-5756)
- Federica Azzolini (ORCID: https://orcid.org/0000-0002-7567-278X)
- Sonia Di Lemme
- Fabio Buttari (ORCID: https://orcid.org/0000-0002-6089-4670)
- Giovanni Galifi (ORCID: https://orcid.org/0000-0002-6929-8795)
- Luana Gilio (ORCID: https://orcid.org/0000-0001-7132-9098)
- Angela Borrelli
Institutions
- University of Rome Tor Vergata (IT)
- Vita-Salute San Raffaele University (IT)
- San Raffaele University of Rome (IT)
- Istituto Neurologico Mediterraneo (IT)
- IRCCS Ospedale San Raffaele (IT)
- UniNettuno University (IT)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1007/s10072-025-08526-8
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00