Robust Estimation of Additive Shared‐Frailty Models for Recurrent Event Data With Dependent Censoring

Recurrent event data with dependent censoring frequently arise in medical follow-up studies. In analyzing such data, one main challenge is addressing the complex dependencies among the recurrent events, failure events, and censoring events. In this paper, we focus on additive shared-frailty models for recurrent event processes and failure times, and propose a robust estimation procedure that accommodates censoring times dependent on both recurrent and failure events, even after conditioning on observed covariates. Notably, our method does not require specifying the exact dependence structure between censoring and recurrent/failure times, nor does it assume a particular frailty distribution. We show that the resulting estimates are consistent and asymptotically normal. We further assess the method's finite-sample performance through simulation studies, and illustrate its practical utility with a hospitalization dataset.

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Publication Details

Journal
Statistics in Medicine
Published
2025-10-01
DOI
https://doi.org/10.1002/sim.70286
Primary Topic
Statistical Methods and Inference
Type
article
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article

Robust Estimation of Additive Shared‐Frailty Models for Recurrent Event Data With Dependent Censoring

Jieli Ding, Xin Chen, Liuquan Sun
Statistics in Medicine
Statistical Methods and Inference
article

Robust Estimation of Additive Shared‐Frailty Models for Recurrent Event Data With Dependent Censoring

Jieli Ding, Xin Chen, Liuquan Sun
article en

Abstract

Recurrent event data with dependent censoring frequently arise in medical follow-up studies. In analyzing such data, one main challenge is addressing the complex dependencies among the recurrent events, failure events, and censoring events. In this paper, we focus on additive shared-frailty models for recurrent event processes and failure times, and propose a robust estimation procedure that accommodates censoring times dependent on both recurrent and failure events, even after conditioning on observed covariates. Notably, our method does not require specifying the exact dependence structure between censoring and recurrent/failure times, nor does it assume a particular frailty distribution. We show that the resulting estimates are consistent and asymptotically normal. We further assess the method's finite-sample performance through simulation studies, and illustrate its practical utility with a hospitalization dataset.

Statistics in MedicineVol. 44(23-24)
Shanghai Lixin University of Accounting and Finance (CN), Chinese Academy of Sciences (CN), Wuhan University (CN), Academy of Mathematics and Systems Science (CN), University of Chinese Academy of Sciences (CN)
Openalex Percentile: Top 74%
Statistical Methods and Inference
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