Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study
DOAC uptake was associated with reduced ICH rates and costs and an initial increase but subsequent decline in gastrointestinal bleeding rates. Despite stable stroke rates, reduced costs suggest potential long-term economic benefits. Our findings support the real-world effectiveness and safety of DOACs.
Authors
- Tianru Wang (ORCID: https://orcid.org/0000-0002-8221-5720)
- Mina Tadrous (ORCID: https://orcid.org/0000-0003-1911-6129)
- Tara Gomes (ORCID: https://orcid.org/0000-0002-1468-1965)
- Tony Antoniou (ORCID: https://orcid.org/0000-0002-6984-8953)
- Daniel McCormack (ORCID: https://orcid.org/0000-0002-3485-6427)
Institutions
- University of Toronto (CA)
- Women's College Hospital (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Institute for Work & Health (CA)
- Unity Health Toronto
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1111/fcp.70051
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39