Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment
We identify STK11 as a novel regulator of IAV attachment and elucidate its mechanistic role in facilitating viral entry. These findings highlight the potential of STK11 to serve as an ideal antiviral target against IAV infection.
Authors
- Meilin Jin (ORCID: https://orcid.org/0000-0002-3145-9434)
- Shengsong Xie (ORCID: https://orcid.org/0000-0002-8301-877X)
- Shaoyu Tu
- Jiahui Zou (ORCID: https://orcid.org/0000-0002-5021-2867)
- Hongbo Zhou (ORCID: https://orcid.org/0000-0002-3954-3972)
- R. Xiao (ORCID: https://orcid.org/0000-0003-3245-3218)
- Hailong Liu (ORCID: https://orcid.org/0000-0001-6663-563X)
- Huimin Sun (ORCID: https://orcid.org/0000-0002-2892-5596)
- Yue Du (ORCID: https://orcid.org/0000-0003-2973-692X)
- Chuhan Xiong
- Didan Luo
- Huanchun Chen
Institutions
- Huazhong Agricultural University (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.059
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00