Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models
Enhanced proteasome activity in perifascicular myofibres is a hallmark of DM; its inhibition, deemed effective in preclinical models, may represent a new therapeutic strategy for this disease.
Authors
- Béatrice Lannes (ORCID: https://orcid.org/0000-0003-2122-2094)
- Daniela Rovito (ORCID: https://orcid.org/0000-0001-5390-5477)
- L. Debrut (ORCID: https://orcid.org/0000-0003-1534-8088)
- Gilles Laverny (ORCID: https://orcid.org/0000-0002-2666-6877)
- Jean‐Baptiste Chanson (ORCID: https://orcid.org/0000-0003-4221-3840)
- Alain Meyer (ORCID: https://orcid.org/0000-0003-0893-6041)
- Daniel Metzger (ORCID: https://orcid.org/0000-0002-5555-046X)
- Simone Perniola (ORCID: https://orcid.org/0000-0001-6918-4731)
- Céline Keime (ORCID: https://orcid.org/0000-0001-7604-3814)
- Margherita Giannini (ORCID: https://orcid.org/0000-0002-4834-5804)
- Bernard Gény (ORCID: https://orcid.org/0000-0002-5824-6359)
- Aleksandra Nadaj-Pakleza
- Anne‐Laure Charles (ORCID: https://orcid.org/0000-0003-3557-2642)
- Giulia Quiring
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Agostino Gemelli University Polyclinic (IT)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1016/j.ard.2025.08.031
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00