Patients with Higher Exacerbation Burden and Eosinophil Counts are More Likely to Require Multiple Biologics for Asthma Control

Patients with more severe asthma and higher maximum eosinophil counts at biologic initiation were more likely to switch therapies, predominantly due to suboptimal response. These findings emphasize the importance of selecting the first biologic carefully and optimizing timing of initiation.

Authors

Ayobami Akenroye (ORCID: https://orcid.org/0000-0002-1909-1470)
Tanawin Nopsopon (ORCID: https://orcid.org/0000-0003-0428-973X)
Alyson N. Brown (ORCID: https://orcid.org/0000-0002-3932-9474)

Institutions

Brigham and Women's Hospital (US)
Harvard University (US)

Publication Details

Journal: Journal of Asthma and Allergy
Published: 2025-10-01
DOI: https://doi.org/10.2147/jaa.s543815
Citations: 1
Primary Topic: Asthma and respiratory diseases
Type: article
Field-Weighted Citation Impact: 1.16

Funders

Brigham and Women's Hospital
National Institutes of Health

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article

Patients with Higher Exacerbation Burden and Eosinophil Counts are More Likely to Require Multiple Biologics for Asthma Control

Ayobami Akenroye, Tanawin Nopsopon, Alyson N. Brown

Oct 1, 2025

1 citations

Journal of Asthma and Allergy

Asthma and respiratory diseases

1.16

article

Patients with Higher Exacerbation Burden and Eosinophil Counts are More Likely to Require Multiple Biologics for Asthma Control

Ayobami Akenroye, Tanawin Nopsopon, Alyson N. Brown

October 1, 2025article en

1 citations

Abstract

Patients with more severe asthma and higher maximum eosinophil counts at biologic initiation were more likely to switch therapies, predominantly due to suboptimal response. These findings emphasize the importance of selecting the first biologic carefully and optimizing timing of initiation.

Journal of Asthma and AllergyVol. Volume 18

Brigham and Women's Hospital (US), Harvard University (US)

Brigham and Women's Hospital, National Institutes of Health

Openalex Percentile: Top 17%

Asthma and respiratory diseases

1.16

DOI Open Access PDF OpenAlex

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