Pure cerebellitis: A Case Report on Rare Presentation of Scrub Typhus Fever

Scrub typhus is an infectious rickettsial disease caused by the bacterium Orientia tsutsugamushi, transmitted through the bite of chigger mites. This illness can manifest in various ways, ranging from a simple tropical fever to complex multi-organ dysfunction, encompassing acute liver failure, renal failure, acute respiratory distress syndrome, myocarditis, septic cardiomyopathies, secondary hemophagocytic lymphohistiocytosis (HLH), and disseminated intravascular coagulation (DIC) among others. While neurological complications can arise in scrub typhus, the exact frequency remains uncertain. One rarely reported neurological complication associated with this condition is cerebellitis. In this specific case report, we detail the clinical experience of a 25-year-old woman who presented with fever and substantial cerebellar dysfunction and was diagnosed with scrub typhus based on serological test ,specifically an IgM enzyme-linked immunosorbent assay (ELISA) blood test. Notably, her MRI scan and blood investigations revealed no abnormalities, and she responded well to antimicrobial and steroid therapy, ultimately experiencing a full recovery without any complications.

Authors

Publication Details

Journal
Journal of Neurology and Neuromedicine
Published
2025-09-22
DOI
https://doi.org/10.29245/2572.942x/2025/3.1321
Primary Topic
Vector-borne infectious diseases
Type
article
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article

Pure cerebellitis: A Case Report on Rare Presentation of Scrub Typhus Fever

Aditi Mohan, Kalam Singh Butola
Journal of Neurology and Neuromedicine
Vector-borne infectious diseases
article

Pure cerebellitis: A Case Report on Rare Presentation of Scrub Typhus Fever

Aditi Mohan, Kalam Singh Butola
article en

Abstract

Scrub typhus is an infectious rickettsial disease caused by the bacterium Orientia tsutsugamushi, transmitted through the bite of chigger mites. This illness can manifest in various ways, ranging from a simple tropical fever to complex multi-organ dysfunction, encompassing acute liver failure, renal failure, acute respiratory distress syndrome, myocarditis, septic cardiomyopathies, secondary hemophagocytic lymphohistiocytosis (HLH), and disseminated intravascular coagulation (DIC) among others. While neurological complications can arise in scrub typhus, the exact frequency remains uncertain. One rarely reported neurological complication associated with this condition is cerebellitis. In this specific case report, we detail the clinical experience of a 25-year-old woman who presented with fever and substantial cerebellar dysfunction and was diagnosed with scrub typhus based on serological test ,specifically an IgM enzyme-linked immunosorbent assay (ELISA) blood test. Notably, her MRI scan and blood investigations revealed no abnormalities, and she responded well to antimicrobial and steroid therapy, ultimately experiencing a full recovery without any complications.

Journal of Neurology and NeuromedicineVol. 9(3)
Openalex Percentile: Top 71%
Vector-borne infectious diseases
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Pure cerebellitis: A Case Report on Rare Presentation of Scrub Typhus Fever — Aditi Mohan, Kalam Singh Butola · Journal of Neurology and Neuromedicine (2025) | TGRS Research Map | TGRS