Subcapsular Hepatic Hemorrhage: An Uncommon and Catastrophic Manifestation of Metastatic Melanoma

Subcapsular hepatic hematoma is a rare but potentially life-threatening manifestation of metastatic melanoma, often presenting with vague abdominal pain and risk of misdiagnosis. We report a 76-year-old man with a history of malignant melanoma who presented with acute epigastric pain radiating to the right shoulder, vomiting, and a syncopal episode. While initial blood tests showed mild leukocytosis and raised lactate, a CT aorta excluded dissection but revealed multiple hepatic metastases with a large subcapsular hematoma and pulmonary nodules. A follow-up CT mesenteric angiogram demonstrated interval hematoma expansion without active bleeding, further metastatic progression, and a segmental pulmonary embolus. Owing to frailty and advanced malignancy, a multidisciplinary team recommended conservative management. This case highlights the diagnostic conundrum of hepatic hemorrhage in melanoma, which may mimic other acute pathologies such as aortic dissection or acute coronary syndrome. Prompt cross-sectional imaging, serial monitoring, and early multidisciplinary input are essential for accurate diagnosis and for balancing intervention risk against quality of life in complex oncology presentations.

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Publication Details

Journal
Cureus
Published
2025-10-07
DOI
https://doi.org/10.7759/cureus.94001
Primary Topic
Brain Metastases and Treatment
Type
article
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0.00
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article

Subcapsular Hepatic Hemorrhage: An Uncommon and Catastrophic Manifestation of Metastatic Melanoma

Harsh A. Shah, Hari Balaji, A Xavier, Nithin Jyothy et al.
Cureus
Brain Metastases and Treatment
article

Subcapsular Hepatic Hemorrhage: An Uncommon and Catastrophic Manifestation of Metastatic Melanoma

Harsh A. Shah, Hari Balaji, A Xavier, Nithin Jyothy, Sandra Toney
article en

Abstract

Subcapsular hepatic hematoma is a rare but potentially life-threatening manifestation of metastatic melanoma, often presenting with vague abdominal pain and risk of misdiagnosis. We report a 76-year-old man with a history of malignant melanoma who presented with acute epigastric pain radiating to the right shoulder, vomiting, and a syncopal episode. While initial blood tests showed mild leukocytosis and raised lactate, a CT aorta excluded dissection but revealed multiple hepatic metastases with a large subcapsular hematoma and pulmonary nodules. A follow-up CT mesenteric angiogram demonstrated interval hematoma expansion without active bleeding, further metastatic progression, and a segmental pulmonary embolus. Owing to frailty and advanced malignancy, a multidisciplinary team recommended conservative management. This case highlights the diagnostic conundrum of hepatic hemorrhage in melanoma, which may mimic other acute pathologies such as aortic dissection or acute coronary syndrome. Prompt cross-sectional imaging, serial monitoring, and early multidisciplinary input are essential for accurate diagnosis and for balancing intervention risk against quality of life in complex oncology presentations.

CureusVol. 17(10)
Maidstone and Tunbridge Wells NHS Trust (GB), Southern Health and Social Care Trust (GB), St.John's Medical College Hospital (IN)
Openalex Percentile: Top 59%
Brain Metastases and Treatment
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