Comprehensive analysis of DNA methylation patterns in recurrent miscarriage: imprinted/non-imprinted genes and their regulation across sperm and fetal-maternal tissues
This study identifies profound epigenetic dysregulation in RM-associated tissues, emphasizing the contribution of imprinting gene methylation abnormalities to pregnancy loss. Future studies incorporating functional assays and animal models are essential to elucidate the causal roles of candidate genes in RM pathogenesis and maternal-fetal health.
Authors
- Yunqinq Li
- Meng Yao (ORCID: https://orcid.org/0000-0002-8906-1461)
- Xiaoyan Pang (ORCID: https://orcid.org/0000-0002-1269-5466)
- Yanru Niu (ORCID: https://orcid.org/0000-0001-7708-5610)
- Kaijie Yang (ORCID: https://orcid.org/0000-0002-7450-205X)
- Guoling Zhang (ORCID: https://orcid.org/0000-0002-2632-0577)
- Yulan Zhou
- Cailing Peng
- Tianzhong Ma
- Lanlan Yin
Institutions
- Guangdong Medical College (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-10-07
- DOI
- https://doi.org/10.7717/peerj.20125
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China