Impact of Substantial Weight Loss on Digoxin Intoxication During Long-term Therapy

Concomitant diuretics and comorbid cancer were risk factors of digoxin intoxication during early treatment, whereas substantial body weight loss ≥ 6% became the risk factor after prolonged treatment, and impaired renal function was the risk factor spanning early to prolonged treatment. Thus, transition of risk factors of digoxin intoxication during prolonged course of treatment was observed.