Expert consensus definition of treatment intolerance in chronic myeloid leukemia in chronic phase
Recognizing that treatment intolerance is influenced by laboratory findings, reported symptoms, and how patients experience their treatment, experts agreed on a patient-centered definition of TKI treatment intolerance in CML-CP. This definition represents a step forward in standardizing care for patients with CML-CP by presenting a balanced framework for managing TKI therapy, which will support shared decision-making.
Authors
- Neil P. Shah (ORCID: https://orcid.org/0000-0003-4398-3388)
- Michael J. Mauro (ORCID: https://orcid.org/0000-0002-2251-4032)
- Michael S. Broder (ORCID: https://orcid.org/0000-0002-2049-5536)
- Marisa Hine
- Anthony Michael Hunter (ORCID: https://orcid.org/0000-0002-9819-4151)
- Jay Yang (ORCID: https://orcid.org/0000-0003-0790-7951)
- Kathryn E. Flynn (ORCID: https://orcid.org/0000-0002-4427-3583)
- Srinivas K. Tantravahi (ORCID: https://orcid.org/0000-0003-4899-3796)
- Jeffrey A. Gilreath (ORCID: https://orcid.org/0000-0002-4566-8448)
- Onyee Chan (ORCID: https://orcid.org/0000-0003-2872-1961)
- Ehab L. Atallah (ORCID: https://orcid.org/0000-0002-9919-3564)
- Hannah Dalglish (ORCID: https://orcid.org/0000-0003-3153-3443)
- Javier Pinilla‐Ibarz (ORCID: https://orcid.org/0000-0003-3170-9648)
- Lindsay Rein (ORCID: https://orcid.org/0000-0002-9888-4814)
- Evan Stemper
Institutions
- University of Wisconsin–Eau Claire (US)
- Memorial Sloan Kettering Cancer Center (US)
- Emory University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Medical College of Wisconsin (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- University of California System (US)
- Moffitt Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- District of Columbia Department of Health (US)
- Healthcentric Advisors (US)
Publication Details
- Journal
- Hematology
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1080/16078454.2025.2556506
- Citations
- 3
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.31