Potential of Limosilactobacillus-Linked 3-OMDP as a Treatment Target in Depression

Although the gut microbiota has been strongly implicated in the development of depression, its precise molecular mechanisms are still poorly understood. This study aimed to clarify the relationship between gut microbial alterations, fluctuations in neurotransmitters, and inflammatory responses in a murine model of depression. A chronic social defeat stress (CSDS) paradigm was used to induce depressive-like states. Fecal samples were analyzed for microbial composition and neurotransmitter levels,