Effect of Meropenem, Sulbactam, and Colistin Combinations on Resistance Gene Expression in Multidrug-Resistant A. baumannii Clinical Isolates from Panama
Therefore, this study offers a new perspective on how rational combinations of clinically used antibiotics have the potential to modulate gene expression and contribute to the control of MDR strains, indicating that high-dose combination therapy with sulbactam and colistin could offer improved efficacy in treating multidrug resistant <i>Acinetobacter baumannii</i> infections.
Authors
- Juan R. Medina-Sánchez (ORCID: https://orcid.org/0000-0002-8137-4017)
- Armando A. Durant-Archibold (ORCID: https://orcid.org/0000-0002-6516-9427)
- Jordi Querol‐Audí (ORCID: https://orcid.org/0000-0003-2892-7599)
- Ariel Magallón Tejada
- J P (ORCID: https://orcid.org/0000-0002-2296-0286)
Institutions
- Universidad de Panamá (PA)
- Instituto Conmemorativo Gorgas de Estudios de la Salud (PA)
- Secretaría Nacional de Ciencia, Tecnología e Innovación (PA)
- Universidad Tecnológica de Panamá (PA)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-10-07
- DOI
- https://doi.org/10.3390/antibiotics14100999
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00