Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis
We identified several genes and pathways in PC tissue potentially associated with the reported beneficial effects of statin treatment in PC. Specifically, we identified an association between statin treatment and intra-tumour LDLR upregulation. This study contributes to the understanding of statin-mediated effects on PC.
Authors
- Benedicte P. Ulhøi (ORCID: https://orcid.org/0009-0000-3551-4173)
- Signe Borgquist (ORCID: https://orcid.org/0000-0001-7938-8893)
- Jacob Fredsøe (ORCID: https://orcid.org/0000-0002-7319-2467)
- Michael Borre (ORCID: https://orcid.org/0000-0002-1519-9185)
- Karina D. Sørensen (ORCID: https://orcid.org/0000-0002-4902-5490)
- Kia Eistrup Fonfara (ORCID: https://orcid.org/0000-0003-4795-5384)
Institutions
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2025-10-07
- DOI
- https://doi.org/10.2340/1651-226x.2025.43788
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitet
- Novo Nordisk
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal