Tumor-Induced Osteomalacia Presenting as Bilateral Intertrochanteric Fractures: A Rare Case Report

Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by phosphate wasting, leading to hypophosphatemia, bone pain, and fractures. Its nonspecific symptoms often delay diagnosis, complicating management. Case Presentation: We report a rare case of a middle-aged patient presenting with bilateral intertrochanteric femur fractures without significant trauma. Biochemical evaluation revealed hypophosphatemia, elevated alkaline phosphatase, and low vitamin D levels. Further investigations identified a phosphaturic mesenchymal tumor responsible for TIO. Surgical excision of the tumor resulted in normalization of phosphate levels and clinical improvement. Conclusion: This case highlights the importance of considering TIO in patients with unexplained fractures and metabolic bone disease. Early diagnosis and tumor localization are critical for effective treatment and prevention of further skeletal complications.

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Publication Details

Journal
Frontiers in Medical and Clinical Sciences
Published
2025-04-01
DOI
https://doi.org/10.64917/fmcs-005
Primary Topic
Management of metastatic bone disease
Type
article
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article

Tumor-Induced Osteomalacia Presenting as Bilateral Intertrochanteric Fractures: A Rare Case Report

Ananya Sharma, Rajesh K. Singh
Frontiers in Medical and Clinical Sciences
Management of metastatic bone disease
article

Tumor-Induced Osteomalacia Presenting as Bilateral Intertrochanteric Fractures: A Rare Case Report

Ananya Sharma, Rajesh K. Singh
article en

Abstract

Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by phosphate wasting, leading to hypophosphatemia, bone pain, and fractures. Its nonspecific symptoms often delay diagnosis, complicating management. Case Presentation: We report a rare case of a middle-aged patient presenting with bilateral intertrochanteric femur fractures without significant trauma. Biochemical evaluation revealed hypophosphatemia, elevated alkaline phosphatase, and low vitamin D levels. Further investigations identified a phosphaturic mesenchymal tumor responsible for TIO. Surgical excision of the tumor resulted in normalization of phosphate levels and clinical improvement. Conclusion: This case highlights the importance of considering TIO in patients with unexplained fractures and metabolic bone disease. Early diagnosis and tumor localization are critical for effective treatment and prevention of further skeletal complications.

Frontiers in Medical and Clinical SciencesVol. 02(04)
Post Graduate Institute of Medical Education and Research (IN), All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 56%
Management of metastatic bone disease
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