Critical insights on real-life PD-L1 histopathological workflow and assessment in esophageal, esophagogastric junction, and gastric carcinoma in Italy
This study confirms the alignment of GEC PD-L1 expression in Italian real-world practice with clinical trials. Inter-institutional variability and the significant influence of preanalytical factors, particularly tissue aging and PD-L1 clone, highlight important challenges in routine PD-L1 testing. Addressing these issues is crucial to enhance the reliability of PD-L1 IHC assessment and ensure optimal patient selection for ICIs in GEC.
Authors
- P. Morbini
- Maria Raffaella Ambrosio (ORCID: https://orcid.org/0000-0002-1172-6902)
- Luca Albarello (ORCID: https://orcid.org/0000-0003-4846-5096)
- Federica Grillo (ORCID: https://orcid.org/0000-0001-6477-3182)
- Federica Castri (ORCID: https://orcid.org/0000-0002-3890-8757)
- Alessandro Gambella (ORCID: https://orcid.org/0000-0001-7826-002X)
- Marta Fortunato (ORCID: https://orcid.org/0000-0002-3539-0307)
- Bruna Cerbelli (ORCID: https://orcid.org/0000-0001-5419-2309)
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Alessandro Vanoli (ORCID: https://orcid.org/0000-0002-2976-7032)
- Alessandro Pastorino (ORCID: https://orcid.org/0000-0003-4207-3665)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Isabella Banchelli
- Stefano La Rosa (ORCID: https://orcid.org/0000-0003-1941-2403)
- Michele Paudice (ORCID: https://orcid.org/0000-0003-4188-4247)
- G Locci
- Stefano Lazzi (ORCID: https://orcid.org/0000-0002-2218-3771)
- Laura Melocchi (ORCID: https://orcid.org/0000-0001-5161-6305)
- Lindsey Savino
- Paola Cassoni (ORCID: https://orcid.org/0000-0003-1977-7410)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Vincenzo Nardini
- Andrea Remo (ORCID: https://orcid.org/0000-0002-2564-2988)
- V. Barresi
- Bruno Spina (ORCID: https://orcid.org/0000-0002-9458-9527)
- Luca Mastracci (ORCID: https://orcid.org/0000-0003-0193-5281)
- Maria Cristina Macciomei (ORCID: https://orcid.org/0000-0002-4199-5636)
- Paola Spaggiari (ORCID: https://orcid.org/0000-0003-2905-1736)
- Iacopo Panarese (ORCID: https://orcid.org/0000-0002-7292-5219)
- M. Martini
- Paola Billo
- Giuseppe De Lisi
- Alessandro Caputo (ORCID: https://orcid.org/0000-0001-5139-3869)
- Bruna Pozzi
- Dennis Fiorini (ORCID: https://orcid.org/0000-0001-5055-6099)
- Enrico Costantino Falco
- Maria DʼArmiento (ORCID: https://orcid.org/0000-0001-7389-3071)
- M.R. Aprile
- F. Sommavilla
Institutions
- University of Salerno (IT)
- University of Padua (IT)
- University of Pavia (IT)
- Casa Sollievo della Sofferenza (IT)
- Agostino Gemelli University Polyclinic (IT)
- University Hospital Foundation (CA)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Genoa (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105846
- Citations
- 2
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01