Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient

Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning—in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan failure.

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Publication Details

Journal
Annals of Internal Medicine Clinical Cases
Published
2025-10-01
DOI
https://doi.org/10.7326/aimcc.2025.0671
Primary Topic
Methemoglobinemia and Tumor Lysis Syndrome
Type
article
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article

Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient

Chelsea Boyd, Brian Drury, Siraj Amanullah, Kelsey Van Housen
Annals of Internal Medicine Clinical Cases
Methemoglobinemia and Tumor Lysis Syndrome
article

Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient

Chelsea Boyd, Brian Drury, Siraj Amanullah, Kelsey Van Housen
article en

Abstract

Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning—in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan failure.

Annals of Internal Medicine Clinical CasesVol. 4(10)
Rhode Island Department of Health (US), Thomas Jefferson University (US), Oregon Health & Science University (US), Baylor College of Medicine (US), Brown University (US), Rhode Island Hospital (US)
Openalex Percentile: Top 60%
Methemoglobinemia and Tumor Lysis Syndrome
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Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient — Chelsea Boyd, Brian Drury, et al. · Annals of Internal Medicine Clinical Cases (2025) | TGRS Research Map | TGRS