Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient
Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning—in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan failure.
Authors
- Chelsea Boyd (ORCID: https://orcid.org/0000-0002-4120-9164)
- Brian Drury (ORCID: https://orcid.org/0000-0001-5918-1801)
- Siraj Amanullah
- Kelsey Van Housen
Institutions
- Rhode Island Department of Health (US)
- Thomas Jefferson University (US)
- Oregon Health & Science University (US)
- Baylor College of Medicine (US)
- Brown University (US)
- Rhode Island Hospital (US)
Publication Details
- Journal
- Annals of Internal Medicine Clinical Cases
- Published
- 2025-10-01
- DOI
- https://doi.org/10.7326/aimcc.2025.0671
- Primary Topic
- Methemoglobinemia and Tumor Lysis Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00