Predominant role of fat mass in the association between HMB and frailty
The relationship between endogenous HMB and frailty is modified by body composition, with a stronger impact mediated by fat mass than lean mass. Future studies should explore the therapeutic implications of HMB supplementation in age-related changes in body composition and frailty.
Authors
- Leocadio Rodríguez‐Mañas (ORCID: https://orcid.org/0000-0002-6551-1333)
- Alejandro Álvarez‐Bustos (ORCID: https://orcid.org/0000-0002-3431-7204)
- A. Santos-Fandila (ORCID: https://orcid.org/0000-0002-7477-5752)
- Ricardo Rueda (ORCID: https://orcid.org/0000-0003-2127-3190)
- Suzette L. Pereira (ORCID: https://orcid.org/0009-0007-9401-7004)
- Begoña Molina‐Baena
- Francisco José García-García
- José Antonio Carranza Carnicero
Institutions
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- ProMedica Toledo Hospital (US)
- Abbott (United States) (US)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Universitario de Getafe (ES)
- Abbott (Spain) (ES)
- Hospital Universitario de La Princesa (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Ross Laboratories (United States) (US)
- Biomedical Research Foundation (BD)
- Complejo Hospitalario Universitario de Toledo (ES)
- Abbott Nutrition (United States)
- Universidad Autónoma de Madrid (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1093/gerona/glaf203
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00