Red-light excitation of a Ru( <scp>ii</scp> )–Pt( <scp>ii</scp> ) tetranuclear complex for combined photoactivated chemotherapy and photodynamic therapy
We report the synthesis and biological evaluation of a tetranuclear Ru(II)-Pt(II) complex activated by red light (630 nm). Upon irradiation, the Ru(II) center photo-catalytically generates singlet oxygen while simultaneously releasing Pt(II) moieties, thereby inducing a multimodal therapeutic effect in cancer cells by photodynamic therapy and photoactivated chemotherapy.
Authors
- Nicolás Montesdeoca (ORCID: https://orcid.org/0000-0002-9629-1265)
- Johannes Karges (ORCID: https://orcid.org/0000-0001-5258-0260)
- Julia Schleisiek
- Eleni Michaltsis
- Pia Siekierski
Institutions
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05177k
- Citations
- 4
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Verband der Chemischen Industrie
- Fonds der Chemischen Industrie
- Aventis Foundation